PCSK5 (Gene)

Entrez Gene ID: 5125

Description: proprotein convertase subtilisin/kexin type 5

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PCSK5's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PCSK5.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PCSK5.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PCSK5.

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Gene Sets (1927)

LINCS L1000 Chem Pert Consensus Sigs (485)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (16)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (19)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (529)

A gene set library provided by LINCS

rummageo gene perturbations (127)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (532)

A gene set library provided by LINCS

rummageo chemical perturbations (215)

A gene set library provided by LINCS

GTEx Tissues V8 2023 (4)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
apixaban Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK5 Gene (Entity type)	0.0044528404
Butenafine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK5 Gene (Entity type)	-0.017172348
choline-alfoscerate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK5 Gene (Entity type)	-0.0039237635
SA-1459167 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK5 Gene (Entity type)	-0.011117746
1-(3-Benzoylsulfanyl-2-methyl-propionyl)-4-phenylsulfanyl-pyrrolidine-2-carboxylic acid (zofenopril) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK5 Gene (Entity type)	-0.0029135442
KFGENEBIN:PCSK5-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	PCSK5 Gene (Entity type)
TMPH Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK5 Gene (Entity type)	-0.012024835
N-(4-acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK5 Gene (Entity type)	-0.008663237
amiloride Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK5 Gene (Entity type)	-0.002795592
OM-137 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK5 Gene (Entity type)	0.00866964

apixaban
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCSK5
Gene (Entity type)
0.0044528404

Butenafine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCSK5
Gene (Entity type)
-0.017172348

choline-alfoscerate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCSK5
Gene (Entity type)
-0.0039237635

SA-1459167
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCSK5
Gene (Entity type)
-0.011117746

1-(3-Benzoylsulfanyl-2-methyl-propionyl)-4-phenylsulfanyl-pyrrolidine-2-carboxylic acid (zofenopril)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCSK5
Gene (Entity type)
-0.0029135442

KFGENEBIN:PCSK5-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
PCSK5
Gene (Entity type)

TMPH
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCSK5
Gene (Entity type)
-0.012024835

N-(4-acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCSK5
Gene (Entity type)
-0.008663237

amiloride
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCSK5
Gene (Entity type)
-0.002795592

OM-137
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCSK5
Gene (Entity type)
0.00866964

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

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