IL12RB1 (Gene)

Organism:

Homo sapiens

Synonyms:CD212, ENTREZ:3594, HGNC:5971, IL-12R-BETA1, IL12RB, IL12RB1, IMD30, MIM:601604, NM_001290023, NM_001290024, NM_005535, NM_153701, NP_001276952, NP_001276953, NP_005526, NP_714912, XM_006722741, XM_011527966, XM_011527967, XM_011527968, XM_011527969, XM_011527970, XM_011527971, XM_011527972, XM_011527973, XM_011527974, XM_011527975, XM_011527976, XM_011527977, XM_017026762, XP_006722804, XP_011526268, XP_011526269, XP_011526270, XP_011526271, XP_011526272, XP_011526273, XP_011526274, XP_011526275, XP_011526276, XP_011526277, XP_011526278, XP_011526279, XP_016882251, interleukin 12 receptor subunit beta 1

Omim:OMIM:601604

Id:ENSG00000096996

Hgnc:HGNC:5971

Entrez:3594

Ensembl:ENSG00000096996

Description:interleukin 12 receptor subunit beta 1

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

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Playbook Workflow Builder: Gene-Centric Workflow

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CFDE Gene-Centric Appyter

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GDLPA Landing Pages Links

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Playbook Workflow Builder

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Results found

Linked to

	Label	Description
	GSE142210 9 V 1 PANOBINOSTAT HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE182680 GSE182683 dexamethasone 5 v 11 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE129698 SYK inhibition 3 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE153871 cytarabine U2OS 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE116810 5 V 4 SELINEXOR HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE114492 GSE153671 KMT2D inhibition 2 v 11 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE228430 FABP5 inhibition Huh-7 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE120612 etoposide leukocyte 4 v 5 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE214480 TMIGD2 knockdown HEL-30 1 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE142210 9 V 0 PANOBINOSTAT HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS

GSE142210 9 V 1 PANOBINOSTAT HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE182680 GSE182683 dexamethasone 5 v 11 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE129698 SYK inhibition 3 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE153871 cytarabine U2OS 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE116810 5 V 4 SELINEXOR HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE114492 GSE153671 KMT2D inhibition 2 v 11 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE228430 FABP5 inhibition Huh-7 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE120612 etoposide leukocyte 4 v 5 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE214480 TMIGD2 knockdown HEL-30 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE142210 9 V 0 PANOBINOSTAT HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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