ME2 (Gene)

Entrez Gene ID: 4200

Description: malic enzyme 2

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ME2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with ME2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using ME2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for ME2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with ME2.

Gene Sets (2012)

LINCS L1000 Chem Pert Consensus Sigs (448)

A gene set library provided by LINCS

Metabolomics Workbench Metabolites 2022 (2)

A gene set library provided by MW

ARCHS4 IDG Coexp (5)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (1)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (569)

A gene set library provided by LINCS

rummageo gene perturbations (140)

A gene set library provided by LINCS

RummaGEO DrugPerturbations 2025 (86)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (497)

A gene set library provided by LINCS

rummageo chemical perturbations (261)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (3)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Reserpic-acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ME2 Gene (Entity type)	0.009466122
spectinomycin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ME2 Gene (Entity type)	0.011607555
L-ascorbyl-6-palmitate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ME2 Gene (Entity type)	0.009360985
Caffeic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ME2 Gene (Entity type)	-0.0069843247
dichlorobenzamil Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ME2 Gene (Entity type)	-0.01109681
SA-426029 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ME2 Gene (Entity type)	0.008679028
Indoximod Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ME2 Gene (Entity type)	0.0032967778
TMI-15 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ME2 Gene (Entity type)	-0.009336452
N-(4-(3-bromophenylamino)quinazolin-6-yl)acrylamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ME2 Gene (Entity type)	-0.007230017
KU-C103656 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ME2 Gene (Entity type)	0.013401954

Reserpic-acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ME2
Gene (Entity type)
0.009466122

spectinomycin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ME2
Gene (Entity type)
0.011607555

L-ascorbyl-6-palmitate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ME2
Gene (Entity type)
0.009360985

Caffeic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ME2
Gene (Entity type)
-0.0069843247

dichlorobenzamil
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ME2
Gene (Entity type)
-0.01109681

SA-426029
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ME2
Gene (Entity type)
0.008679028

Indoximod
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ME2
Gene (Entity type)
0.0032967778

TMI-15
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ME2
Gene (Entity type)
-0.009336452

N-(4-(3-bromophenylamino)quinazolin-6-yl)acrylamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ME2
Gene (Entity type)
-0.007230017

KU-C103656
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ME2
Gene (Entity type)
0.013401954

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.