FGFR3 (Gene)

Organism:

Homo sapiens

Synonyms:ACH, CD333, CEK2, ENTREZ:2261, FGFR3, HGNC:3690, HSFGFR3EX, JTK4, MIM:134934, NM_000142, NM_001163213, NM_001354809, NM_001354810, NM_022965, NP_000133, NP_001156685, NP_001341738, NP_001341739, NP_075254, NR_148971, XM_006713868, XM_006713869, XM_006713870, XM_006713871, XM_006713873, XM_011513420, XM_011513422, XP_006713931, XP_006713932, XP_006713933, XP_006713934, XP_006713936, XP_011511722, XP_011511724, fibroblast growth factor receptor 3

Omim:OMIM:134934

Id:ENSG00000068078

Hgnc:HGNC:3690

Entrez:2261

Ensembl:ENSG00000068078

Description:fibroblast growth factor receptor 3

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View FGFR3's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with FGFR3.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using FGFR3.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for FGFR3.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with FGFR3.

Results found

Linked to

	Label	Description
	GSE118548 trametinib T84 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE226525 GSE226527 HNRNPH2 knockout 4 v 8 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE199859 A-7 HCA7 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE118816 Myo1c knockdown podocyte 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE118548 1 V 2 TRAMETINIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE119424 GSE120214 TBXT brachyury inhibition 7 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE156761 dopamine neuron 0 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE133927 PTEN p53 Meox1 knockdown BT-549 RNA Small Interfering 1 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS

GSE118548 trametinib T84 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE226525 GSE226527 HNRNPH2 knockout 4 v 8 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE199859 A-7 HCA7 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE118816 Myo1c knockdown podocyte 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE118548 1 V 2 TRAMETINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE119424 GSE120214 TBXT brachyury inhibition 7 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE156761 dopamine neuron 0 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE133927 PTEN p53 Meox1 knockdown BT-549 RNA Small Interfering 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

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Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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