CFDE Workbench
InfoDataCloudKnowledgetrainingcoordination
Search
Graph
Enrichment
Cross
Assistant
Data Matrix
Use Cases
Tools & Workflows
Submit
Documentation
CFDE Workbench

SPI1 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ENTREZ:6688, HGNC:11241, MIM:165170, NM_001080547, NM_003120, NP_001074016, NP_003111, OF, PU.1, SFPI1, SPI-1, SPI-A, SPI1, Spi-1 proto-oncogene, XM_011520307, XM_017018173, XP_011518609, XP_016873662
Omim:OMIM:165170
Id:ENSG00000066336
Hgnc:HGNC:11241
Entrez:6688
Ensembl:ENSG00000066336
Description:Spi-1 proto-oncogene
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SPI1's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with SPI1.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SPI1.

Submit
Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SPI1.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SPI1.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE176008 pyridoxine 4 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE182150 KIT LSD1 MYC inhibition 2 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE176008 pyridoxine 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE176008 4 V 1 AZACITIDINE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE147662 3 V 5 NICOTINAMIDE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE115384 CELSR2 knockdown 2 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE147705 USP7 inhibition K-562 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE114492 GSE153671 KMT2D inhibition 2 v 11 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE201309 matrine 1 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE115384 CELSR2 knockdown 6 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE176008 pyridoxine 4 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE182150 KIT LSD1 MYC inhibition 2 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE176008 pyridoxine 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE176008 4 V 1 AZACITIDINE HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE147662 3 V 5 NICOTINAMIDE MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE115384 CELSR2 knockdown 2 v 7 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE147705 USP7 inhibition K-562 1 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE114492 GSE153671 KMT2D inhibition 2 v 11 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE201309 matrine 1 v 6 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE115384 CELSR2 knockdown 6 v 7 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

    • DISPLAY PER PAGE
    CFDE Workbench
    Report a bug
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    @CFDE Workbench 2026
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.