CACNA2D2 (Gene)

Organism:

Homo sapiens

Synonyms:CACNA2D, CACNA2D2, CASVDD, ENTREZ:9254, HGNC:1400, MIM:607082, NM_001005505, NM_001174051, NM_001291101, NM_006030, NP_001005505, NP_001167522, NP_001278030, NP_006021, XM_005265581, XM_011534243, XP_005265638, XP_011532545, calcium voltage-gated channel auxiliary subunit alpha2delta 2

Omim:OMIM:607082

Id:ENSG00000007402

Hgnc:HGNC:1400

Entrez:9254

Ensembl:ENSG00000007402

Description:calcium voltage-gated channel auxiliary subunit alpha2delta 2

Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

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Playbook Workflow Builder: Gene-Centric Workflow

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CFDE Gene-Centric Appyter

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GDLPA Landing Pages Links

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Playbook Workflow Builder

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Results found

Linked to

	Label	Description
	GSE233647 docetaxel UFERSA-PC3 DU145 4 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE115542 digoxin 5 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	Ataxia Phenotype (Entity type)	Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...
	GSE199859 A-7 HCA7 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE197422 GSE197424 FN1 overexpression HGC-27 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE147876 GSE147877 enzalutamide MR42D 2 v 10 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE233647 4 V 0 DOCETAXEL HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE261563 CX-5461 5 v 8 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE156761 dopamine neuron 0 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE174745 dopamine neuron 1 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE233647 docetaxel UFERSA-PC3 DU145 4 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE115542 digoxin 5 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Ataxia

Phenotype (Entity type)

Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...

GSE199859 A-7 HCA7 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE197422 GSE197424 FN1 overexpression HGC-27 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE147876 GSE147877 enzalutamide MR42D 2 v 10 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE233647 4 V 0 DOCETAXEL HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE261563 CX-5461 5 v 8 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE156761 dopamine neuron 0 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE174745 dopamine neuron 1 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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