CHEK1 (Gene)

Description: checkpoint kinase 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CHEK1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CHEK1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CHEK1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CHEK1.

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Gene Sets (973)

LINCS L1000 Chem Pert Consensus Sigs (581)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (5)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (380)

A gene set library provided by LINCS

IDG Drug Targets 2022 (7)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
MW-STK33-2C Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CHEK1 Gene (Entity type)	0.013495035
Estrone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CHEK1 Gene (Entity type)	0.0027737194
SA-1922796 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CHEK1 Gene (Entity type)	0.016484074
(S)-1-[2-(3-Hydroxy-adamantan-1-ylamino)-acetyl]-pyrrolidine-2-carbonitrile Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CHEK1 Gene (Entity type)	0.004271334
SID11113468 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CHEK1 Gene (Entity type)	-0.008135988
Dimemorfan Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CHEK1 Gene (Entity type)	0.0052532447
docosahexaenoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CHEK1 Gene (Entity type)	-0.008870256
KFGENEBIN:CHEK1-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	CHEK1 Gene (Entity type)
SA-432137 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CHEK1 Gene (Entity type)	-0.008852238
STF-62247 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CHEK1 Gene (Entity type)	-0.02062814