PCSK1 (Gene)

Description: proprotein convertase subtilisin/kexin type 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PCSK1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PCSK1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PCSK1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PCSK1.

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Gene Sets (1803)

LINCS L1000 Chem Pert Consensus Sigs (791)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (6)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (2)

A gene set library provided by GlyGen

KOMP2 Mouse Phenotypes 2022 (7)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (987)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (5)

A gene set library provided by GTEx

GTEx Tissues V8 2023 (5)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
fluspirilene Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK1 Gene (Entity type)	-0.003603271
Trichloroethylene Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK1 Gene (Entity type)	-0.010804258
SA-1921816 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK1 Gene (Entity type)	0.023838937
methyl-testosterone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK1 Gene (Entity type)	0.013718397
tezampanel Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK1 Gene (Entity type)	0.0054032146
KDM-096 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK1 Gene (Entity type)	0.014473555
merestinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK1 Gene (Entity type)	-0.0056397477
PH-797804 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK1 Gene (Entity type)	-0.003205595
2-methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl)propanenitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK1 Gene (Entity type)	-0.022488266
dinorcitalopram-oxalate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK1 Gene (Entity type)	0.014708308