TLR4 (Gene)

Description: toll like receptor 4

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TLR4's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TLR4.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TLR4.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TLR4.

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Gene Sets (2700)

LINCS L1000 Chem Pert Consensus Sigs (1917)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (14)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (4)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (762)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (2)

A gene set library provided by GTEx

IDG Drug Targets 2022 (1)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Pemoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.008444417
SA-101776 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	0.031686
rel-Milnacipran Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.005372375
norcyclobenzaprine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.010531745
UBP-302 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	0.008786698
Tetrachloroethylene Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.009845448
Sulfametopyrazine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.021530092
monoethylhexylphthalate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	0.011603028
Hispidin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	-0.01461531
Mepenzolate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLR4 Gene (Entity type)	0.015154593