PHGDH (Gene)

Description: phosphoglycerate dehydrogenase

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PHGDH's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PHGDH.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PHGDH.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PHGDH.

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Gene Sets (898)

LINCS L1000 Chem Pert Consensus Sigs (724)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (6)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (20)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (144)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (2)

A gene set library provided by GTEx

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (2)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

Source	Relation	Target	Evidence
KFGENEBIN:PHGDH-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)
SID103905231 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)	0.0075864815
3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)	0.0037087193
5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)	-0.019950174
GW-6471 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)	0.008980955
(5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)	-0.018758155
N'-((5-methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)	0.007977773
venetoclax Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)	0.0033692655
ezetimibe Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)	0.007890707
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PHGDH Gene (Entity type)	0.013427399